Immunity to Fasciola hepatica in the rat

Experiments were carried out which demonstrated an acquired immunity to Fasciola hepatica in the rat. It was shown that this immunity could be transferred to recipients using either lymphoid cells or serum from infected donor rats. The extent of the protection obtained by cells appeared to be relate...

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Veröffentlicht in:	Experimental parasitology 1974-06, Vol.35 (3), p.381-388
Hauptverfasser:	Armour, J., Dargie, J.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	560153 -Biomedical Sciences, Applied Studies-Radiation Effects-Radiation Effects on Animals-Invertebrates FASCIOLA- BIOLOGICAL RADIATION EFFECTS FASCIOLIASIS- IMMUNE REACTIONS GAMMA RADIATION IMMUNE REACTIONS IMMUNE SERUMS LYMPHOCYTES N48530 -Life Sciences-Radiation Effects on Animals- Invertebrates RATS
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Beschreibung
Zusammenfassung:	Experiments were carried out which demonstrated an acquired immunity to Fasciola hepatica in the rat. It was shown that this immunity could be transferred to recipients using either lymphoid cells or serum from infected donor rats. The extent of the protection obtained by cells appeared to be related to the quantity and persistence of the antigenic stimulus in the donor. Likewise, the degree of immunity conferred by immune serum was dependent upon the volume transferred. Finally, the significance of these results in relation to the mechanism of immunity to fascioliasis is discussed.
ISSN:	0014-4894 1090-2449
DOI:	10.1016/0014-4894(74)90044-7