LincRNA-RoR/miR-145 promote invasion and metastasis in triple-negative breast cancer via targeting MUC1
Triple-negative breast cancer (TNBC) was associated with high rates of cancer recurrence and metastasis and currently no available molecularly target. Accumulating evidences have established the importance of lincRNA-ROR as a marker of cancers. In order to better understand the mechanism of lincRNA-...
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Veröffentlicht in: | Biochemical and biophysical research communications 2018-06, Vol.500 (3), p.614-620 |
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Sprache: | eng |
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Zusammenfassung: | Triple-negative breast cancer (TNBC) was associated with high rates of cancer recurrence and metastasis and currently no available molecularly target. Accumulating evidences have established the importance of lincRNA-ROR as a marker of cancers. In order to better understand the mechanism of lincRNA-ROR in TNBC, we provided a novel molecular target into the regulatory invasion and metastasis in present research. We found that lincRNA-ROR was upregulated in TNBC cell lines and tissue samples. The aberrant expression of lincRNA-ROR was shown to increase invasion and metastasis in MDA-MB-231 and loss of function by siRNA reverse these process. Furthermore, lincRNA-ROR functions as a competing endogenous RNAs (ceRNA) which sponges miR-145 and therefore upregulate the expression of Mucin1 (MUC1). The expression of MUC1 impacted E-cadherin membrane localization. Together, MUC1 was a potential molecular target may help explain the role of lincRNA-ROR/miR-145 for invasion and metastasis in TNBC cell lines.
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•LincRNA-ROR was upregulated in TNBC cell lines and tissue samples.•LincRNA-ROR was able to significantly promote the invasion and metastasis of TNBC cell lines MDA-MB-231.•LincRNA-ROR/miR-145 regulated invasion and metastasis of MDA-MB-231 via the target MUC1. |
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ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1016/j.bbrc.2018.04.119 |