LncRNA MALAT1 is up-regulated in diabetic gastroparesis and involved in high-glucose-induced cellular processes in human gastric smooth muscle cells

LncRNA MALAT1 is up-regulated in diabetic gastroparesis and involved in high-glucose-induced cellular processes in human gastric smooth muscle cells

Recent years, widespread long non-coding RNAs (lncRNAs) were identified and known as regulator of gene expression. Diabetic gastroparesis (DGP) is one of the most common chronic complications of diabetes mellitus. There was no research reported the role of lncRNAs in DGP. In this study, we firstly e...

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Veröffentlicht in:Biochemical and biophysical research communications 2018-02, Vol.496 (2), p.401-406
Hauptverfasser: Gong, Yaoyao, Zhu, Ying, Zhu, Boqian, Si, Xinmin, Heng, Ding, Tang, Yurong, Sun, Xiaomeng, Lin, Lin
Format: Artikel
Sprache:eng
Schlagworte:
60 APPLIED LIFE SCIENCES
DIABETES MELLITUS
Diabetic gastroparesis
GLUCOSE
High-glucose stimulation
Human gastric smooth muscle cells
lncRNA MALAT1
MYOSIN
RATS
RNA
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Zusammenfassung:Recent years, widespread long non-coding RNAs (lncRNAs) were identified and known as regulator of gene expression. Diabetic gastroparesis (DGP) is one of the most common chronic complications of diabetes mellitus. There was no research reported the role of lncRNAs in DGP. In this study, we firstly established a rat model of DGP by STZ injection. Then, we detected the expression of MALAT1 and found that expression of MALAT1 was up-regulated in rat model of DGP, comparing to the control group (P 
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2018.01.038