DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway

The DEAD-box-protein DDX5 is an ATP-dependent RNA helicase and also acts as co-activator that contributes to progression and metastasis of various tumours. However, its expression as well as prognostic roles of DDX5 in hepatocellular carcinoma (HCC) remain elusive. In this study, we investigated cli...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-09, Vol.503 (4), p.2885-2891
Hauptverfasser:	Xue, Ying, Jia, Xuebing, Li, Lei, Dong, Xiao, Ling, Jing, Yuan, Jian, Li, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Akt BIOLOGICAL FUNCTIONS Carcinogenesis Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell Proliferation Cells, Cultured DDX5 DEAD-box RNA Helicases - analysis DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism HCC HEPATOMAS Humans Liver Neoplasms - etiology Liver Neoplasms - mortality Liver Neoplasms - pathology METASTASES Proliferation PROTEINS Proto-Oncogene Proteins c-akt - metabolism RNA Survival Analysis Tumorigenesis
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Zusammenfassung:	The DEAD-box-protein DDX5 is an ATP-dependent RNA helicase and also acts as co-activator that contributes to progression and metastasis of various tumours. However, its expression as well as prognostic roles of DDX5 in hepatocellular carcinoma (HCC) remain elusive. In this study, we investigated clinical significance and biological functions of DDX5 in HCC. Our results suggested that DDX5 showed overexpression at both transcriptional and translational levels in HCC tissues compared with adjacent normal tissues. Moreover, DDX5 expression was demonstrated to be correlated with tumor size (p
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2018.08.063