Structure-activity relationships of novel dithiocarbamates containing α,β-unsaturated ketone fragment as potent anticancer agents

Structure-activity relationships of novel dithiocarbamates containing α,β-unsaturated ketone fragment as potent anticancer agents

Based on the structure of novel lead compound 8 discovered by our group, systematic structural modification was carried out. A series of compound 8 ’s derivatives were synthesized and evaluated for their activities against human non-small cell lung cancer cell line H460. Among them, twelve compounds...

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Veröffentlicht in:Medicinal chemistry research 2019-07, Vol.28 (7), p.1027-1038
Hauptverfasser: Wang, Yuanqiang, Li, Ridong, Zhang, Han, Zhang, Zhiyong, Wang, Xin, Ge, Zemei, Li, Runtao
Format: Artikel
Sprache:eng
Schlagworte:
60 APPLIED LIFE SCIENCES
Anticancer properties
Antitumor agents
BENZENE
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
CAVITIES
Cell Biology
Hydrophobicity
KETONES
LEAD COMPOUNDS
LUNGS
NEOPLASMS
Non-small cell lung carcinoma
Original Research
Pharmacology/Toxicology
RECEPTORS
Small cell lung carcinoma
STRUCTURE-ACTIVITY RELATIONSHIPS
Tumor cell lines
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Zusammenfassung:Based on the structure of novel lead compound 8 discovered by our group, systematic structural modification was carried out. A series of compound 8 ’s derivatives were synthesized and evaluated for their activities against human non-small cell lung cancer cell line H460. Among them, twelve compounds showed significant proliferation inhibition activities with IC 50 values
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-019-02356-y