Probing Mechanical Characteristics of Living Fibroblasts via Atomic Force Microscopy

Probing Mechanical Characteristics of Living Fibroblasts via Atomic Force Microscopy

Atomic force microscopy (AFM) measurements have revealed hardening of intact fibroblasts after treatment with colchicine. The reliability of AFM measurements was confirmed by the identification of cells the lateral response of which to indentation did not disturb the normal force contribution. AFM d...

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Veröffentlicht in:Technical physics letters 2019-09, Vol.45 (9), p.947-950
Hauptverfasser: Timoshchuk, K. I., Khalisov, M. M., Penniyaynen, V. A., Krylov, B. V., Ankudinov, A. V.
Format: Artikel
Sprache:eng
Schlagworte:
ATOMIC AND MOLECULAR PHYSICS
ATOMIC FORCE MICROSCOPY
Classical and Continuum Physics
COLCHICINE
FIBROBLASTS
HARDENING
Indentation
MATERIALS SCIENCE
MECHANICAL PROPERTIES
Microscopes
Microscopy
Physics
Physics and Astronomy
PROBES
RELIABILITY
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Zusammenfassung:Atomic force microscopy (AFM) measurements have revealed hardening of intact fibroblasts after treatment with colchicine. The reliability of AFM measurements was confirmed by the identification of cells the lateral response of which to indentation did not disturb the normal force contribution. AFM data on the mechanical characteristics of such cells admit an unambiguous interpretation.
ISSN:1063-7850
1090-6533
DOI:10.1134/S1063785019090293