Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells
We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2019-04, Vol.166 (6), p.785-787 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 166 |
| creator | Bozhenko, V. K. Ivanov, A. V. Kulinich, T. M. Smirnov, V. P. Shishkin, A. M. Solodky, V. A. |
| description | We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation with ultra-high dose rate induced significantly higher levels of “early” apoptosis and lower levels of necrosis compared to γ-radiation with dose rate used for radiation therapy. |
| doi_str_mv | 10.1007/s10517-019-04440-0 |
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| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2019-04, Vol.166 (6), p.785-787 |
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| subjects | 60 APPLIED LIFE SCIENCES APOPTOSIS BIOLOGICAL EFFECTS Biomedical and Life Sciences Biomedicine Cell activation Cell Biology CELL CULTURES Cell death DOSE RATES Gamma rays Internal Medicine Laboratory Medicine LYMPHOCYTES Lymphocytes B Lymphocytes T Lymphoma LYMPHOMAS NECROSIS Pathology Radiation therapy RADIOTHERAPY γ Radiation |
| title | Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells |
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