Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells

We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-04, Vol.166 (6), p.785-787
Hauptverfasser:	Bozhenko, V. K., Ivanov, A. V., Kulinich, T. M., Smirnov, V. P., Shishkin, A. M., Solodky, V. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES APOPTOSIS BIOLOGICAL EFFECTS Biomedical and Life Sciences Biomedicine Cell activation Cell Biology CELL CULTURES Cell death DOSE RATES Gamma rays Internal Medicine Laboratory Medicine LYMPHOCYTES Lymphocytes B Lymphocytes T Lymphoma LYMPHOMAS NECROSIS Pathology Radiation therapy RADIOTHERAPY γ Radiation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation with ultra-high dose rate induced significantly higher levels of “early” apoptosis and lower levels of necrosis compared to γ-radiation with dose rate used for radiation therapy.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04440-0