Folate receptor alpha is associated with cervical carcinogenesis and regulates cervical cancer cells growth by activating ERK1/2/c-Fos/c-Jun

Folate receptor alpha (FRα) is over-expressed in numerous epithelial malignancies, however, the association between FRα and cervical cancer remains unclear. The purpose of this study was to explore the effects of FRα on cervical cancer and its regulation of the ERK signaling pathway. In this case-co...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-09, Vol.491 (4), p.1083-1091
Hauptverfasser:	Liu, Chunliang, Ding, Ling, Bai, Lixia, Chen, Xiao, Kang, Huijie, Hou, Lifang, Wang, Jintao
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adult Aged APOPTOSIS c-Fos c-Jun CARCINOGENESIS CARCINOMAS CELL CYCLE CELL PROLIFERATION Cervical cancer ERK1/2 Female Folate Receptor 1 - metabolism Folate receptor alpha Humans IN VITRO Middle Aged Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - metabolism RECEPTORS SIGNALS THERAPY Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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Zusammenfassung:	Folate receptor alpha (FRα) is over-expressed in numerous epithelial malignancies, however, the association between FRα and cervical cancer remains unclear. The purpose of this study was to explore the effects of FRα on cervical cancer and its regulation of the ERK signaling pathway. In this case-control study, moderate/strong expression of FRα, phosphorylated ERK1/2 (p-ERK1/2), p-c-Fos, and p-c-Jun proteins was increased with the progressive severity of cervix lesions (P
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2017.08.015