Life, death and tolerance

•CD95 triggers death as well as non-death activities - e.g. proliferation, invasion and inflammation.•The CD95-Fc fusion protein, APG101, can serve as a tool to manipulate CD95-mediated non-death and death events.•The manipulation of the new immunological Annexin checkpoint system has an impact on p...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-01, Vol.482 (3), p.470-472
Hauptverfasser:	Krammer, Peter H., Weyd, Heiko
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Annexins - metabolism APOPTOSIS Apoptosis - immunology Apoptosis signaling CADMIUM 95 DEATH Death Domain Receptor Signaling Adaptor Proteins - metabolism Dysregulation of cell death fas Receptor - metabolism Humans Immunoglobulin G - metabolism INFLAMMATION Mice Neoplasms - immunology Neoplasms - pathology Peripheral Tolerance PROLIFERATION PROTEINS Recombinant Fusion Proteins - metabolism SIGNALS TOLERANCE
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Beschreibung
Zusammenfassung:	•CD95 triggers death as well as non-death activities - e.g. proliferation, invasion and inflammation.•The CD95-Fc fusion protein, APG101, can serve as a tool to manipulate CD95-mediated non-death and death events.•The manipulation of the new immunological Annexin checkpoint system has an impact on peripheral tolerance towards apoptotic cells.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2016.10.123