Perfluorooctanoic acid affects endocytosis involving clathrin light chain A and microRNA-133b-3p in mouse testes

Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. Among its potential health hazards, testicular toxicity is of major concern. To explore the potential effect of miRNA on post-translational regulation after PFOA exposure, change...

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Veröffentlicht in:	Toxicology and applied pharmacology 2017-03, Vol.318, p.41-48
Hauptverfasser:	Lu, Yin, Wang, Jianshe, Guo, Xuejiang, Yan, Shengmin, Dai, Jiayin
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals APOLIPOPROTEINS BLOOD Caprylates - toxicity Clathrin Light Chains - biosynthesis CLTA CONSUMER PRODUCTS Endocytosis Endocytosis - drug effects Endocytosis - physiology Fluorocarbons - toxicity GENE REGULATION GROWTH FACTORS HEALTH HAZARDS IN VITRO LUCIFERASE Male MICE Mice, Inbred BALB C MicroRNAs - biosynthesis miRNA Perfluorooctanoic acid Protein Interaction Maps - drug effects Protein Interaction Maps - physiology Random Allocation RECEPTORS SERINE TESTES Testis - drug effects Testis - metabolism
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Zusammenfassung:	Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. Among its potential health hazards, testicular toxicity is of major concern. To explore the potential effect of miRNA on post-translational regulation after PFOA exposure, changes in miRNAs were detected via miRNA array. Seventeen miRNAs were differentially expressed (eight upregulated, nine downregulated) in male mouse testes after exposure to 5mg/kg/d of PFOA for 28d (>1.5-fold and P
ISSN:	0041-008X 1096-0333
DOI:	10.1016/j.taap.2017.01.014