Assessing interactions of binary mixtures of Penicillium mycotoxins (PMs) by using a bovine macrophage cell line (BoMacs)

Penicillium mycotoxins (PMs) are toxic contaminants commonly found as mixtures in animal feed. Therefore, it is important to investigate potential joint toxicity of PM mixtures. In the present study, we assessed the joint effect of binary combinations of the following PMs: citrinin (CIT), ochratoxin...

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Veröffentlicht in:	Toxicology and applied pharmacology 2017-03, Vol.318, p.33-40
Hauptverfasser:	Oh, Se-Young, Cedergreen, Nina, Yiannikouris, Alexandros, Swamy, H.V.L.N., Karrow, Niel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ABUNDANCE ANIMAL FEEDS Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - toxicity BINARY MIXTURES CATTLE Cell Line CELL PROLIFERATION Cell Proliferation - drug effects Cell Proliferation - physiology Citrinin - chemistry Citrinin - metabolism Citrinin - toxicity Concentration addition (CA) CONCENTRATION RATIO DILUTION Dose-Response Relationship, Drug Drug Interactions - physiology HEALTH HAZARDS Independent action (IA) Interaction MACROPHAGES Macrophages - drug effects Macrophages - metabolism Mixture toxicity MYCOTOXINS Mycotoxins - chemistry Mycotoxins - metabolism Mycotoxins - toxicity Ochratoxins - chemistry Ochratoxins - metabolism Ochratoxins - toxicity PENICILLIUM Penicillium - chemistry Penicillium - metabolism Penicillium mycotoxins SYNERGISM TOXICITY
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Zusammenfassung:	Penicillium mycotoxins (PMs) are toxic contaminants commonly found as mixtures in animal feed. Therefore, it is important to investigate potential joint toxicity of PM mixtures. In the present study, we assessed the joint effect of binary combinations of the following PMs: citrinin (CIT), ochratoxin A (OTA), patulin (PAT), mycophenolic acid (MPA) and penicillic acid (PA) using independent action (IA) and concentration addition (CA) concepts. Previously published toxicity data (i.e. IC25; PM concentration that inhibited bovine macrophage (BoMacs) proliferation by 25%) were initially analyzed, and both concepts agreed that OTA+PA demonstrated synergism (p
ISSN:	0041-008X 1096-0333
DOI:	10.1016/j.taap.2017.01.015