A Novel Form of Breast Intraoperative Radiation Therapy With CT-Guided High-Dose-Rate Brachytherapy: Results of a Prospective Phase 1 Clinical Trial

Purpose Existing intraoperative radiation therapy (IORT) techniques are criticized for the lack of image guided treatment planning and energy deposition with, at times, poor resultant dosimetry and low radiation dose. We pioneered a novel method of IORT that incorporates customized, computed tomogra...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2016-09, Vol.96 (1), p.46-54
Hauptverfasser:	Showalter, Shayna L., MD, Petroni, Gina, PhD, Trifiletti, Daniel M., MD, Libby, Bruce, PhD, Schroen, Anneke T., MD, MPH, Brenin, David R., MD, Dalal, Parchayi, BA, Smolkin, Mark, MS, Reardon, Kelli A., MD, Showalter, Timothy N., MD, MPH
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged BRACHYTHERAPY Brachytherapy - adverse effects Brachytherapy - methods Breast Neoplasms - diagnostic imaging Breast Neoplasms - radiotherapy CLINICAL TRIALS Combined Modality Therapy - adverse effects Combined Modality Therapy - methods COMPUTERIZED TOMOGRAPHY CONSUMER PRODUCTS CT-GUIDED RADIOTHERAPY Dose Fractionation DOSE RATES DOSIMETRY Feasibility Studies Female GY RANGE 10-100 Hematology, Oncology and Palliative Medicine Humans Intraoperative Care - methods MAMMARY GLANDS Mastectomy - methods Middle Aged NEOPLASMS PATIENTS RADIATION DOSES Radiation Injuries - etiology Radiation Injuries - prevention & control Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy Dosage Radiotherapy, Image-Guided - methods STANDARD OF LIVING Tomography, X-Ray Computed - methods TOXICITY Treatment Outcome
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Zusammenfassung:	Purpose Existing intraoperative radiation therapy (IORT) techniques are criticized for the lack of image guided treatment planning and energy deposition with, at times, poor resultant dosimetry and low radiation dose. We pioneered a novel method of IORT that incorporates customized, computed tomography (CT)-based treatment planning and high-dose-rate (HDR) brachytherapy to overcome these drawbacks: CT-HDR-IORT. Methods and Materials A phase 1 study was conducted to demonstrate the feasibility and safety of CT-HDR-IORT. Eligibility criteria included age ≥50 years, invasive or in situ breast cancer, tumor size
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2016.04.035