TROP2 overexpression promotes proliferation and invasion of lung adenocarcinoma cells

Recent studies suggest that the human trophoblast cell-surface antigen TROP2 is highly expressed in a number of tumours and is correlated with poor prognosis. However, its role in non-small cell lung carcinoma (NSCLC) remains largely unknown. Here we examined TROP2 expression by immunohistochemistry...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-01, Vol.470 (1), p.197-204
Hauptverfasser:	Li, Zanhua, Jiang, Xunsheng, Zhang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged ANIMAL TISSUES ANTIGENS Antigens, Neoplasm - metabolism APOPTOSIS BIOLOGICAL MARKERS Biomarkers, Tumor - metabolism CARCINOMAS Cell Adhesion Molecules - metabolism Cell Line, Tumor CELL PROLIFERATION China - epidemiology Humans Invasion Lung adenocarcinoma Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology LUNGS LYMPH LYMPH NODES METASTASES Middle Aged Migration MULTIVARIATE ANALYSIS Neoplasm Invasiveness PATIENTS Prevalence Proliferation Reproducibility of Results Risk Factors Sensitivity and Specificity Survival Rate TROP2 Up-Regulation
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Zusammenfassung:	Recent studies suggest that the human trophoblast cell-surface antigen TROP2 is highly expressed in a number of tumours and is correlated with poor prognosis. However, its role in non-small cell lung carcinoma (NSCLC) remains largely unknown. Here we examined TROP2 expression by immunohistochemistry in a series of 68 patients with adenocarcinoma (ADC). We found significantly elevated TROP2 expression in ADC tissues compared with normal lung tissues (P
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2016.01.032