Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets

A high-fat diet (HF) is associated with obesity, insulin resistance, and hyperglycemia. Animal studies have shown compensatory mechanisms in pancreatic β-cells after high fat load, such as increased pancreatic β-cell mass, enhanced insulin secretion, and exocytosis. However, the effects of high fat...

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Veröffentlicht in:Biochemical and biophysical research communications 2015-03, Vol.458 (3), p.681-686
Hauptverfasser: Kanno, Ayumi, Asahara, Shun-Ichiro, Masuda, Katsuhisa, Matsuda, Tomokazu, Kimura-Koyanagi, Maki, Seino, Susumu, Ogawa, Wataru, Kido, Yoshiaki
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Sprache:eng
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