Natural Oil-Based Emulsion Containing Allantoin Versus Aqueous Cream for Managing Radiation-Induced Skin Reactions in Patients With Cancer: A Phase 3, Double-Blind, Randomized, Controlled Trial
Purpose To investigate the effects of a natural oil-based emulsion containing allantoin versus aqueous cream for preventing and managing radiation-induced skin reactions. Methods and Materials A total of 174 patients were randomized and participated in the study. Patients received either cream 1 (th...
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Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2014-11, Vol.90 (4), p.756-764 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Purpose To investigate the effects of a natural oil-based emulsion containing allantoin versus aqueous cream for preventing and managing radiation-induced skin reactions. Methods and Materials A total of 174 patients were randomized and participated in the study. Patients received either cream 1 (the natural oil-based emulsion containing allantoin) or cream 2 (aqueous cream). Skin toxicity, pain, itching, and skin-related quality of life scores were collected for up to 4 weeks after radiation treatment. Results Patients who received cream 1 had a significantly lower average level of Common Terminology Criteria for Adverse Events at week 3 ( P |
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ISSN: | 0360-3016 1879-355X |
DOI: | 10.1016/j.ijrobp.2014.06.034 |