Natural Oil-Based Emulsion Containing Allantoin Versus Aqueous Cream for Managing Radiation-Induced Skin Reactions in Patients With Cancer: A Phase 3, Double-Blind, Randomized, Controlled Trial

Purpose To investigate the effects of a natural oil-based emulsion containing allantoin versus aqueous cream for preventing and managing radiation-induced skin reactions. Methods and Materials A total of 174 patients were randomized and participated in the study. Patients received either cream 1 (th...

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Veröffentlicht in:International journal of radiation oncology, biology, physics biology, physics, 2014-11, Vol.90 (4), p.756-764
Hauptverfasser: Chan, Raymond Javan, RN, BN, MAppSc(Research), PhD, FACN, Mann, Jennifer, RN, BN, GradCertHlthSc, Tripcony, Lee, BSc, Keller, Jacqui, BBus(HIM), Cheuk, Robyn, BMBS, FRANZCR, Blades, Rae, RN, BN, GradCertNursing, Keogh, Samantha, RN, PhD, Poole, Christopher, BEng, MSc, PhD, Walsh, Christopher, BAppSc
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Sprache:eng
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Zusammenfassung:Purpose To investigate the effects of a natural oil-based emulsion containing allantoin versus aqueous cream for preventing and managing radiation-induced skin reactions. Methods and Materials A total of 174 patients were randomized and participated in the study. Patients received either cream 1 (the natural oil-based emulsion containing allantoin) or cream 2 (aqueous cream). Skin toxicity, pain, itching, and skin-related quality of life scores were collected for up to 4 weeks after radiation treatment. Results Patients who received cream 1 had a significantly lower average level of Common Terminology Criteria for Adverse Events at week 3 ( P
ISSN:0360-3016
1879-355X
DOI:10.1016/j.ijrobp.2014.06.034