Risk of Local Failure in Breast Cancer Patients With Lobular Carcinoma In Situ at the Final Surgical Margins: Is Re-excision Necessary?

Purpose To compare the outcome of patients with invasive breast cancer both with and without lobular carcinoma in situ (LCIS)-positive/close surgical margins after breast-conserving treatment. Methods and Materials We retrospectively studied 2358 patients with T1-T2 invasive breast cancer treated wi...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2013-11, Vol.87 (4), p.726-730
Hauptverfasser:	Sadek, Betro T., MD, Shenouda, Mina N., MD, Abi Raad, Rita F., MD, Niemierko, Andrzej, PhD, Keruakous, Amany R., MD, Goldberg, Saveli I., PhD, Taghian, Alphonse G., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Carcinoma in Situ - pathology Carcinoma in Situ - radiotherapy Carcinoma in Situ - surgery Carcinoma, Lobular - pathology Carcinoma, Lobular - radiotherapy Carcinoma, Lobular - surgery CARCINOMAS CHEMOTHERAPY Female Hematology, Oncology and Palliative Medicine Humans LYMPH NODES MAMMARY GLANDS Mastectomy, Segmental Middle Aged Neoplasm Recurrence, Local Neoplasm, Residual PATIENTS Proportional Hazards Models Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Reoperation Retrospective Studies Risk SURGERY Treatment Failure Unnecessary Procedures Young Adult
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Zusammenfassung:	Purpose To compare the outcome of patients with invasive breast cancer both with and without lobular carcinoma in situ (LCIS)-positive/close surgical margins after breast-conserving treatment. Methods and Materials We retrospectively studied 2358 patients with T1-T2 invasive breast cancer treated with lumpectomy and radiation therapy from January 1980 to December 2009. Median age was 57 years (range, 24-91 years). There were 82 patients (3.5%) with positive/close LCIS margins (
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2013.08.012