Studying the protein expression in human B lymphoblastoid cells exposed to 1.8-GHz (GSM) radiofrequency radiation (RFR) with protein microarray

► Protein microarray shows the differential expression of 27 proteins induced by RFR. ► RPA32 related to DNA repair is down-regulated in Western blot. ► p73 related to cell genome stability and apoptosis is up-regulated in Western blot. In the present study, the protein microarray was used to invest...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-03, Vol.433 (1), p.36-39
Hauptverfasser:	Zhijian, Chen, Xiaoxue, Li, Wei, Zheng, Yezhen, Lu, Jianlin, Lou, Deqiang, Lu, Shijie, Chen, Lifen, Jin, Jiliang, He
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ABSORPTION APOPTOSIS Apoptosis - radiation effects BIOLOGICAL EFFECTS CELL CYCLE Cell Cycle - radiation effects Cell Line CELL PROLIFERATION Cell Proliferation - radiation effects Cell Transformation, Neoplastic - radiation effects DNA DAMAGES DNA REPAIR DNA Repair - radiation effects DNA-Binding Proteins - metabolism DNA-Binding Proteins - radiation effects Down-Regulation - radiation effects Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - radiation effects Nuclear Proteins - metabolism Nuclear Proteins - radiation effects p73 Precursor Cells, B-Lymphoid - metabolism Precursor Cells, B-Lymphoid - radiation effects Protein Array Analysis Protein microarray PROTEINS Proteins - metabolism Proteins - radiation effects Radio Waves - adverse effects Radiofrequency radiation RADIOWAVE RADIATION Replication Protein A Replication Protein A - metabolism Replication Protein A - radiation effects Tumor Protein p73 Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - radiation effects Up-Regulation - radiation effects
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Zusammenfassung:	► Protein microarray shows the differential expression of 27 proteins induced by RFR. ► RPA32 related to DNA repair is down-regulated in Western blot. ► p73 related to cell genome stability and apoptosis is up-regulated in Western blot. In the present study, the protein microarray was used to investigate the protein expression in human B-cell lymphoblastoid cells intermittently exposed to 1.8-GHz GSM radiofrequency radiation (RFR) at the specific absorption rate (SAR) of 2.0W/kg for 24h. The differential expression of 27 proteins was found, which were related to DNA damage repair, apoptosis, oncogenesis, cell cycle and proliferation (ratio >1.5-fold, P
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2013.02.071