Radiation-Free Weekend Rescued! Continuous Accelerated Irradiation of 7-Days per Week Is Equal to Accelerated Fractionation With Concomitant Boost of 7 Fractions in 5-Days per Week: Report on Phase 3 Clinical Trial in Head-and-Neck Cancer Patients

Purpose To report long-term results of randomized trial comparing 2 accelerated fractionations of definitive radiation therapy assessing the need to irradiate during weekend in patients with head and neck squamous cell carcinoma. Methods and Materials A total of 345 patients with SCC of the oral cav...

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Veröffentlicht in:International journal of radiation oncology, biology, physics biology, physics, 2013-03, Vol.85 (3), p.741-746
Hauptverfasser: Skladowski, Krzysztof, MD, PhD, Hutnik, Marcin, MD, Wygoda, Andrzej, MD, PhD, Golen, Maria, MD, PhD, Pilecki, Boleslaw, MD, PhD, Przeorek, Wieslawa, MD, PhD, Rutkowski, Tomasz, MD, PhD, Lukaszczyk-Widel, Beata, MD, Heyda, Alicja, MA, Suwinski, Rafal, MD, PhD, Tarnawski, Rafal, MD, PhD, Maciejewski, Boguslaw, MD, PhD
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Sprache:eng
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Zusammenfassung:Purpose To report long-term results of randomized trial comparing 2 accelerated fractionations of definitive radiation therapy assessing the need to irradiate during weekend in patients with head and neck squamous cell carcinoma. Methods and Materials A total of 345 patients with SCC of the oral cavity, larynx, and oro- or hypo-pharynx, stage T2-4N0-1M0, were randomized to receive continuous accelerated irradiation (CAIR: once per day, 7 days per week) or concomitant accelerated boost (CB: once per day, 3 days per week, and twice per day, 2 days per week). Total dose ranged from 66.6-72 Gy, dose per fraction was 1.8 Gy, number of fractions ranged from 37-40 fractions, and overall treatment time ranged from 37-40 days. Results No differences for all trial end-points were noted. At 5 and 10 years, the actuarial rates of local-regional control were 63% and 60% for CAIR vs 65% and 60% for CB, and the corresponding overall survival were 40% and 25% vs 44% and 25%, respectively. Confluent mucositis was the main acute toxicity, with an incidence of 89% in CAIR and 86% in CB patients. The 5-year rate of grade 3-4 late radiation morbidity was 6% for both regimens. Conclusions Results of this trial indicate that the effects of accelerated fractionation can be achieve by delivering twice-per-day irradiation on weekday(s). This trial has also confirmed that an accelerated, 6-weeks schedule is a reasonable option for patients with intermediate-stage head-and-neck squamous cell carcinoma because of the associated high cure rate and minimal severe late toxicity.
ISSN:0360-3016
1879-355X
DOI:10.1016/j.ijrobp.2012.06.037