Everolimus-induced Pneumonitis after Drug-eluting Stent Implantation: A Case Report

Despite the wide use of everolimus as an antineoplastic coating agent for coronary stents to reduce the rate of restenosis, little is known about the health hazards of everolimus-eluting stents (EES). We describe a case of pneumonitis that developed 2 months after EES implantation for angina. Lung p...

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Veröffentlicht in:	Cardiovascular and interventional radiology 2013-08, Vol.36 (4), p.1151-1154
Hauptverfasser:	Sakamoto, Susumu, Kikuchi, Naoshi, Ichikawa, Atsuo, Sano, Go, Satoh, Keita, Sugino, Keishi, Isobe, Kazutoshi, Takai, Yujiro, Shibuya, Kazutoshi, Homma, Sakae
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angina Pectoris - diagnostic imaging Angina Pectoris - therapy Angioplasty, Balloon, Coronary - adverse effects Angioplasty, Balloon, Coronary - methods Cardiology Case Report CORONARIES Coronary Restenosis - diagnostic imaging Coronary Restenosis - therapy Coronary Stenosis - diagnostic imaging Coronary Stenosis - therapy CORTICOSTEROIDS Drug-Eluting Stents - adverse effects DRUGS Everolimus Follow-Up Studies HEALTH HAZARDS Humans Imaging ISCHEMIA LUNGS Male Medicine Medicine & Public Health NEOPLASMS Nuclear Medicine Paclitaxel - therapeutic use PATHOLOGY PNEUMONIA Pneumonia - diagnostic imaging Pneumonia - drug therapy Pneumonia - etiology PNEUMONITIS Prednisolone - therapeutic use Radiography, Thoracic RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE Retreatment Risk Assessment Sirolimus - administration & dosage Sirolimus - adverse effects Sirolimus - analogs & derivatives THERAPY Tomography, X-Ray Computed - methods Treatment Outcome Ultrasound
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Zusammenfassung:	Despite the wide use of everolimus as an antineoplastic coating agent for coronary stents to reduce the rate of restenosis, little is known about the health hazards of everolimus-eluting stents (EES). We describe a case of pneumonitis that developed 2 months after EES implantation for angina. Lung pathology demonstrated an organizing pneumonia pattern that responded to corticosteroid therapy. Although the efficacy of EES for ischemic heart disease is well established, EES carries a risk of pneumonitis.
ISSN:	0174-1551 1432-086X
DOI:	10.1007/s00270-012-0477-y