Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2)

Purpose To determine the efficacy of a definitive radiotherapy protocol using high-dose-rate intracavitary brachytherapy (HDR-ICBT) with a low cumulative dose schedule in nonbulky early-stage cervical cancer patients, we conducted a prospective multi-institutional study. Methods and Materials Eligib...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2012, Vol.82 (1), p.e49-e56
Hauptverfasser:	Toita, Takafumi, M.D., Ph.D, Kato, Shingo, M.D., Ph.D, Niibe, Yuzuru, M.D., Ph.D, Ohno, Tatsuya, M.D., Ph.D, Kazumoto, Tomoko, M.D., Ph.D, Kodaira, Takeshi, M.D., Ph.D, Kataoka, Masaaki, M.D., Ph.D, Shikama, Naoto, M.D., Ph.D, Kenjo, Masahiro, M.D., Ph.D, Tokumaru, Sunao, M.D, Yamauchi, Chikako, M.D., Ph.D, Suzuki, Osamu, M.D., Ph.D, Sakurai, Hideyuki, M.D., Ph.D, Numasaki, Hodaka, Ph.D, Teshima, Teruki, M.D., Ph.D, Oguchi, Masahiko, M.D., Ph.D, Kagami, Yoshikazu, M.D., Ph.D, Nakano, Takashi, M.D., Ph.D, Hiraoka, Masahiro, M.D., Ph.D, Mitsuhashi, Norio, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged BEAMS BLADDER BRACHYTHERAPY Brachytherapy - methods Carcinoma of the cervix Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - secondary CARCINOMAS Disease-Free Survival DOSE RATES Dose response Dose-Response Relationship, Radiation Female GYNECOLOGY Hematology, Oncology and Palliative Medicine High-dose-rate Humans Intracavitary brachytherapy METASTASES Middle Aged Neoplasm Recurrence, Local Neoplasm Staging NMR IMAGING PATIENTS PELVIS Prospective Studies QUALITY ASSURANCE RADIATION DOSES Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy RECTUM Rectum - radiation effects Relative Biological Effectiveness SCHEDULES SMALL INTESTINE TOXICITY Tumor Burden Urinary Bladder - radiation effects Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy Young Adult
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Zusammenfassung:	Purpose To determine the efficacy of a definitive radiotherapy protocol using high-dose-rate intracavitary brachytherapy (HDR-ICBT) with a low cumulative dose schedule in nonbulky early-stage cervical cancer patients, we conducted a prospective multi-institutional study. Methods and Materials Eligible patients had squamous cell carcinoma of the intact uterine cervix, Federation of Gynecologic Oncology and Obstetrics (FIGO) stages Ib1, IIa, and IIb, tumor size
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2011.01.022