Modified SBA-15 as the carrier for metoprolol and papaverine: Adsorption and release study

A series of modified SBA-15 materials were applied in drug delivery systems. The internal surface of siliceous hexagonal structure of SBA-15 was modified with different amount of (3-mercaptopropyl)trimethoxysilane (MPTMS) and oxidized in the presence of hydrogen peroxide. The sulfonated material was...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of solid state chemistry 2011-07, Vol.184 (7), p.1761-1767
Hauptverfasser: Moritz, MichaŁ, łaniecki, Marek
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A series of modified SBA-15 materials were applied in drug delivery systems. The internal surface of siliceous hexagonal structure of SBA-15 was modified with different amount of (3-mercaptopropyl)trimethoxysilane (MPTMS) and oxidized in the presence of hydrogen peroxide. The sulfonated material was loaded with metoprolol tartrate or papaverine hydrochloride. Both drugs indicated strong chemical interaction with modified mesoporous surface. The characteristic of the obtained materials was performed with XRD and DRUV-vis spectrometry, themogravimetry and nitrogen adsorption (BET) measurements. The obtained results show that modification of the mesoporous materials leads towards significant decrease of the drug delivery rate. XRD and DSC of the –SO 3H modified SBA-15 loaded with metoprolol. [Display omitted] ► Modification of SBA-15 internal channels with SO 3H groups. ► Adsorption of metoprolol and papaverine on modified SBA-15. ► Uniform and homogeneous distribution of the drugs inside the mesoporous structure of SBA-15. ► Release of the supported drugs.
ISSN:0022-4596
1095-726X
DOI:10.1016/j.jssc.2011.05.015