Is Radiation Indicated in Patients With Ductal Carcinoma In Situ and Close or Positive Mastectomy Margins?

Purpose Resection margin status is one of the most significant factors for local recurrence in patients with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery with or without radiation. However, its impact on chest wall recurrence in patients treated with mastectomy is unknown....

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2011-05, Vol.80 (1), p.25-30
Hauptverfasser:	Chan, Linda W., M.D, Rabban, Joseph, M.D., M.P.H, Hwang, E. Shelley, M.D., M.P.H, Bevan, Alison, M.D., Ph.D, Alvarado, Michael, M.D, Ewing, Cheryl, M.D, Esserman, Laura, M.D., M.B.A, Fowble, Barbara, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Axilla Biological and medical sciences BODY Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Carcinoma in Situ - pathology Carcinoma in Situ - radiotherapy Carcinoma in Situ - surgery Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - radiotherapy Carcinoma, Ductal, Breast - surgery CARCINOMAS CHEST DISEASES Ductal carcinoma in situ Female GLANDS Hematology, Oncology and Palliative Medicine Humans Local recurrence Lymph Node Excision - methods MAMMARY GLANDS Margin status Mastectomy Mastectomy, Segmental - methods Medical sciences MEDICINE Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm, Residual NEOPLASMS NUCLEAR MEDICINE ORGANS RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy, Adjuvant SURGERY Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland THERAPY Thoracic Wall Tumor Burden WALLS
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Zusammenfassung:	Purpose Resection margin status is one of the most significant factors for local recurrence in patients with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery with or without radiation. However, its impact on chest wall recurrence in patients treated with mastectomy is unknown. The purpose of this study was to determine chest wall recurrence rates in women with DCIS and close (5 cm or diffuse disease. Median width of the close final margin was 2 mm. Nineteen patients had margins of
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2010.01.044