Phase I Three-Dimensional Conformal Radiation Dose Escalation Study in Newly Diagnosed Glioblastoma: Radiation Therapy Oncology Group Trial 98-03

Purpose To evaluate in a Phase I trial the feasibility and toxicity of dose-escalated three-dimensional conformal radiotherapy (3D-CRT) concurrent with chemotherapy in patients with primary supratentorial glioblastoma (GBM). Methods and Materials A total of 209 patients were enrolled. All received 4...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2009-03, Vol.73 (3), p.699-708
Hauptverfasser:	Tsien, Christina, M.D, Moughan, Jennifer, M.S, Michalski, Jeff M., M.D., M.B.A, Gilbert, Mark R., M.D, Purdy, James, Ph.D, Simpson, Joseph, M.D., Ph.D, Kresel, John J., M.D., Ph.D, Curran, Walter J., M.D, Diaz, Aidnag, M.D, Mehta, Minesh P., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	3D-CRT Adult Aged Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - adverse effects Brain - pathology Brain - radiation effects Carmustine - administration & dosage Carmustine - adverse effects CENTRAL NERVOUS SYSTEM CHEMOTHERAPY Combined Modality Therapy - adverse effects Combined Modality Therapy - methods Dose escalation Drug Administration Schedule Feasibility Studies Female Glioblastoma Glioblastoma - drug therapy Glioblastoma - radiotherapy Glioblastoma - surgery GLIOMAS Hematology, Oncology and Palliative Medicine Humans Male Maximum Tolerated Dose Middle Aged NECROSIS Necrosis - pathology PATIENTS Prospective Studies Quality Control RADIATION DOSES RADIATION HAZARDS Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Radiotherapy, Conformal - adverse effects Radiotherapy, Conformal - methods Radiotherapy, Conformal - standards Reoperation Steroids - administration & dosage Supratentorial Neoplasms - drug therapy Supratentorial Neoplasms - radiotherapy Supratentorial Neoplasms - surgery Survival Analysis TOXICITY Young Adult
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Zusammenfassung:	Purpose To evaluate in a Phase I trial the feasibility and toxicity of dose-escalated three-dimensional conformal radiotherapy (3D-CRT) concurrent with chemotherapy in patients with primary supratentorial glioblastoma (GBM). Methods and Materials A total of 209 patients were enrolled. All received 46 Gy in 2-Gy fractions to the first planning target volume (PTV1 ), defined as the gross tumor volume (GTV) plus 1.8 cm. A subsequent boost was given to PTV2 , defined as GTV plus 0.3 cm. Patients were stratified into two groups (Group 1: PTV2
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2008.05.034