Simulation model based on non-newtonian fluid mechanics applied to the evaluation of the embolic effect of emulsions of iodized oil and anticancer drug

To verify the difference in embolic effect between oil-in-water (O-W) and water-in-oil (W-O) emulsions composed of iodized oil and an anticancer drug, epirubicin, using a simulation model based on non-Newtonian fluid mechanics. Flow curves of pure iodized oil and two types of O-W and W-O emulsions i...

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Veröffentlicht in:Cardiovascular and interventional radiology 2000-07, Vol.23 (4), p.285-290
Hauptverfasser: DEMACHI, Hiroshi, MATSUI, Osamu, ABO, Hitoshi, TATSU, Hiroki
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Sprache:eng
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Zusammenfassung:To verify the difference in embolic effect between oil-in-water (O-W) and water-in-oil (W-O) emulsions composed of iodized oil and an anticancer drug, epirubicin, using a simulation model based on non-Newtonian fluid mechanics. Flow curves of pure iodized oil and two types of O-W and W-O emulsions immediately and 1 hr after preparation were examined with a viscometer. Using the yield stress data obtained, we simulated the stagnation of each fluid with steady flow in a rigid tube. The W-O emulsions were observed to stagnate in the thin tube at a low pressure gradient. However, the embolic effect of the W-O emulsions decreased 1 hr after preparation. The O-W emulsions were stable and did not stagnate under the conditions in which the W-O emulsions stagnated. The simulation model showed that the embolic effect of the W-O emulsions was superior to that of the O-W emulsions.
ISSN:0174-1551
1432-086X
DOI:10.1007/s002700010070