Lumpectomy Plus Tamoxifen or Anastrozole With or Without Whole Breast Irradiation in Women With Favorable Early Breast Cancer

Purpose: In women with favorable early breast cancer treated by lumpectomy plus tamoxifen or anastrazole, it remains unclear whether whole breast radiotherapy is beneficial. Methods and Material: Between January 1996 and June 2004, the Austrian Breast and Colorectal Cancer Study Group (ABCSG) random...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2007-06, Vol.68 (2), p.334-340
Hauptverfasser:	Pötter, Richard, M.D, Gnant, Michael, M.D, Kwasny, Werner, M.D, Tausch, Christoph, M.D, Handl-Zeller, Leonore, M.D, Pakisch, Brigitte, M.D, Taucher, Susanne, M.D, Hammer, Josef, M.D, Luschin-Ebengreuth, Gero, M.D, Schmid, Marianne, M.D, Sedlmayer, Felix, M.D, Stierer, Michael, M.D, Reiner, Georg, M.D, Kapp, Karin, M.D, Hofbauer, Friedrich, M.D, Rottenfusser, Andrea, M.D, Pöstlberger, Sabine, M.D, Haider, Karin, M.D, Draxler, Wolfgang, M.Sc, Jakesz, Raimund, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Agents, Hormonal - therapeutic use Breast irradiation Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery CARCINOMAS ESTROGENS Female Hematology, Oncology and Palliative Medicine Humans IRRADIATION Lumpectomy plus hormone therapy with/without irradiation LYMPH NODES MAMMARY GLANDS Mastectomy, Segmental METASTASES Middle Aged Neoplasm Recurrence, Local Nitriles - therapeutic use PATIENTS PROGESTERONE Prospective Studies Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage RECEPTORS SURGERY Survival Rate TAMOXIFEN Tamoxifen - therapeutic use Triazoles - therapeutic use WOMEN Women with favorable early breast cancer
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Zusammenfassung:	Purpose: In women with favorable early breast cancer treated by lumpectomy plus tamoxifen or anastrazole, it remains unclear whether whole breast radiotherapy is beneficial. Methods and Material: Between January 1996 and June 2004, the Austrian Breast and Colorectal Cancer Study Group (ABCSG) randomly assigned 869 women to receive breast radiotherapy ± boost ( n = 414) or not ( n = 417) after breast-conserving surgery (ABCSG Study 8A). Favorable early breast cancer was specified as tumor size
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2006.12.045