Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma

Purpose: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma. Methods and Materials: Surgical specimens of esophageal SCC ( n = 34) and GEJ adenocarcinoma ( n = 32) were prospectively c...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2007-02, Vol.67 (2), p.389-396
Hauptverfasser:	Gao, Xian-shu, M.D, Qiao, Xueying, M.D, Wu, Fengpeng, M.D, Cao, Li, M.D, Meng, Xianli, M.D, Dong, Zhiming, M.D, Wang, Xiaoling, M.D, Gao, Guodong, M.D, Wu, Tsung-Teh, M.D., Ph.D, Komaki, Ritsuko, M.D, Chang, Joe Y., M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnostic imaging Adenocarcinoma - pathology Adenocarcinoma - radiotherapy Adenocarcinoma - surgery Adenocarcinoma of gastroesophageal junction Adult Aged Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - surgery CARCINOMAS Clinical target volume Esophageal carcinoma Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - pathology Esophageal Neoplasms - radiotherapy Esophageal Neoplasms - surgery Esophagectomy Esophagogastric Junction - diagnostic imaging Esophagogastric Junction - pathology Esophagogastric Junction - surgery ESOPHAGUS Female Hematology, Oncology and Palliative Medicine Humans Lymph node metastasis LYMPH NODES Lymphatic Metastasis Male METASTASES Microscopic spread Middle Aged Neoplasm Staging - methods PATIENTS Prospective Studies Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY SURGERY Tomography, X-Ray Computed
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Zusammenfassung:	Purpose: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma. Methods and Materials: Surgical specimens of esophageal SCC ( n = 34) and GEJ adenocarcinoma ( n = 32) were prospectively collected and analyzed for microscopic spread along the esophagus and GEJ both proximally and distally from gross tumor and for lymph node (LN) metastasis. Results: For SCC, the mean microscopic spread beyond the gross tumor was 10.5 ± 13.5 mm proximally (
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2006.09.015