Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p -nitrobenzoic acid in fungi

Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p -nitrobenzoic acid in fungi

The brevijanazines are novel -nitrobenzoylated piperazines isolated from . Their structures were elucidated by spectroscopic analysis, X-ray crystallography and total synthesis. Heterologous biosynthesis, precursor feeding and microsomal assays unveiled the biosynthetic pathway to the brevijanazines...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-05, Vol.58 (43), p.6296-6299
Hauptverfasser: Li, Hang, Mirzayans, Paul M, Butler, Mark S, Lacey, Alastair E, Vuong, Daniel, Chen, Rachel, Kalaitzis, John A, Moggach, Stephen A, Lacey, Ernest, Piggott, Andrew M, Chooi, Yit-Heng
Format: Artikel
Sprache:eng
Schlagworte:
Aspergillus
Biosynthesis
Biosynthetic Pathways
Chemistry
Crystallography
Cytochromes P450
Fungi - chemistry
Molecular Structure
Nitrobenzoates
Nitrobenzoic acid
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Zusammenfassung:The brevijanazines are novel -nitrobenzoylated piperazines isolated from . Their structures were elucidated by spectroscopic analysis, X-ray crystallography and total synthesis. Heterologous biosynthesis, precursor feeding and microsomal assays unveiled the biosynthetic pathway to the brevijanazines, featuring a cytochrome P450 oxygenase that converts -aminobenzoic acid to -nitrobenzoic acid.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc01679f