Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates

The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Additionally, both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in ce...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-10, Vol.57 (85)
Hauptverfasser:	Huang, Zhouyang, King, A. Paden, Lovett, James, Lai, Barry, Woods, Joshua J., Harris, Hugh H., Wilson, Justin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Online-Zugang:	Volltext
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Zusammenfassung:	The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Additionally, both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.
ISSN:	1359-7345 1364-548X