How to Discover Antiviral Drugs Quickly

Molecular-dynamics simulations together with virtual high-throughput screening provide a means of quick evaluation of existing drugs for antiviral activity. The authors explain how these methods serve in the quest for drugs to treat Covid-19.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-06, Vol.382 (23), p.2261-2264
Hauptverfasser:	Parks, Jerry M, Smith, Jeremy C
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Antiviral activity Antiviral agents Antiviral Agents - therapeutic use Antiviral drugs Betacoronavirus - drug effects Betacoronavirus - genetics Betacoronavirus - ultrastructure Binding sites Computational Biology Computer Simulation Computing Methodologies Coronavirus Infections - drug therapy Coronaviruses COVID-19 Drug development Drug Discovery - methods Drugs genetics High-throughput screening High-Throughput Screening Assays HIV Human immunodeficiency virus Humans Laboratories Models, Biological Pandemics Pneumonia, Viral - drug therapy Proteins R&D Research & development RNA polymerase SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Simulation Supercomputers viral infections
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Beschreibung
Zusammenfassung:	Molecular-dynamics simulations together with virtual high-throughput screening provide a means of quick evaluation of existing drugs for antiviral activity. The authors explain how these methods serve in the quest for drugs to treat Covid-19.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMcibr2007042