Ultrasonically assisted preparation of poly(acrylic acid)/calcium phosphate hybrid nanogels as pH-responsive drug carriers

Biocompatible, biodegradable and stimuli-responsive nanomaterials can be used as drug carriers and to achieve controlled drug delivery, which is crucial for treating tumors and lowering drug side effects. Calcium phosphate (CaP) nanoparticles and poly(acrylic acid) (PAA) hydrogels can be used as bio...

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Veröffentlicht in:	Materials Science & Engineering C 2017-11, Vol.80 (C), p.688-697
Hauptverfasser:	Li, Fang, Xing, Qingguo, Han, Yingchao, Li, Yue, Wang, Wei, Perera, Thalagalage Shalika Harshani, Dai, Honglian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic acid Acrylic Resins Bearing strength Biocompatibility Biodegradability Biodegradation Calcium Calcium phosphate Calcium Phosphates Cancer Controlled delivery Crosslinking Cytotoxicity Doxorubicin Drug Carriers Drug delivery Drug delivery systems Hybrid nanogels Hydrogels Hydrogen ions Hydrogen-Ion Concentration Materials science Nanomaterials Nanoparticles Nanotechnology pH effects pH-sensitive drug carriers Phosphates Poly(acrylic acid) Polyethylene Glycols Polyethyleneimine Reticuloendothelial system Side effects Studies Toxicity Tumors Ultrasonic synthesis Ultrasonics Ultrasound
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Beschreibung
Zusammenfassung:	Biocompatible, biodegradable and stimuli-responsive nanomaterials can be used as drug carriers and to achieve controlled drug delivery, which is crucial for treating tumors and lowering drug side effects. Calcium phosphate (CaP) nanoparticles and poly(acrylic acid) (PAA) hydrogels can be used as biocompatible and pH-responsive drug carriers. In this study, based on the ultrasound effect, PAA/CaP hybrid nanogels (approximately 100nm, PDI
ISSN:	0928-4931 1873-0191
DOI:	10.1016/j.msec.2017.07.022