Crystal Structure of d‑Ornithine/d‑Lysine Decarboxylase, a Stereoinverting Decarboxylase: Implications for Substrate Specificity and Stereospecificity of Fold III Decarboxylases

Crystal Structure of d‑Ornithine/d‑Lysine Decarboxylase, a Stereoinverting Decarboxylase: Implications for Substrate Specificity and Stereospecificity of Fold III Decarboxylases

A newly discovered Fold III pyridoxal 5′-phosphate (PLP)-dependent decarboxylase, d-ornithine/lysine decarboxylase (DOKDC), catalyzes decarboxylation of d-lysine and d-ornithine with inversion of stereochemistry. The X-ray crystal structure of DOKDC has been determined to 1.72 Å. DOKDC has a low lev...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemistry (Easton) 2019-02, Vol.58 (8), p.1038-1042
Hauptverfasser: Phillips, Robert S, Poteh, Pafe, Krajcovic, Donovan, Miller, Katherine A, Hoover, Timothy R
Format: Artikel
Sprache:eng
Schlagworte:
BASIC BIOLOGICAL SCIENCES
chemical specificity
chemical structure
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
monomers
organic reactions
peptides and proteins
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A newly discovered Fold III pyridoxal 5′-phosphate (PLP)-dependent decarboxylase, d-ornithine/lysine decarboxylase (DOKDC), catalyzes decarboxylation of d-lysine and d-ornithine with inversion of stereochemistry. The X-ray crystal structure of DOKDC has been determined to 1.72 Å. DOKDC has a low level of sequence identity (
ISSN:0006-2960
1520-4995
DOI:10.1021/acs.biochem.8b01319