Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

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Veröffentlicht in:	Journal of medicinal chemistry 2017-04, Vol.60 (7), p.3002-3019
Hauptverfasser:	Planken, Simon, Behenna, Douglas C., Nair, Sajiv K., Johnson, Theodore O., Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G., Dinh, Dac M., Edwards, Martin P., Ferre, Rose Ann, Gajiwala, Ketan S., Hemkens, Michelle, Kania, Robert S., Kath, John C., Matthews, Jean, Murray, Brion W., Niessen, Sherry, Orr, Suvi T. M., Pairish, Mason, Sach, Neal W., Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L., Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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