Integrative genomic and proteomic profiling of human neuroblastoma SH-SY5Y cells reveals signatures of endosulfan exposure

Highlights • Endosulfan persistance in the environment is a matter of apprehension. • Integrative ‘omic’ approach is applied to identify molecular signatures. • We report gene and protein signatures in endosulfan exposed SH-SY5Y cells. • This could be useful in development of specific biomarkers for...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-01, Vol.41 (C), p.187-194
Hauptverfasser:	Gandhi, Deepa, Tarale, Prashant, Naoghare, Pravin K, Bafana, Amit, Kannan, Krishnamurthi, Sivanesan, Saravanadevi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Survival - drug effects Emergency Endosulfan Endosulfan - toxicity Gene Expression Profiling Gene Expression Regulation - drug effects Gene Regulatory Networks - drug effects Genomics Humans Insecticides - toxicity Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma cells (SH-SY5Y) Oligonucleotide Array Sequence Analysis Proteomics
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Beschreibung
Zusammenfassung:	Highlights • Endosulfan persistance in the environment is a matter of apprehension. • Integrative ‘omic’ approach is applied to identify molecular signatures. • We report gene and protein signatures in endosulfan exposed SH-SY5Y cells. • This could be useful in development of specific biomarkers for endosulfan exposure.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.11.021