A lipid membrane intercalating conjugated oligoelectrolyte enables electrode driven succinate production in Shewanella

An amphiphilic conjugated oligoelectrolyte (COE) that spontaneously intercalates into lipid membranes enables Shewanella oneidensisto use a graphite electrode as the sole electron donor for succinate production. Current consumed in a poised electrochemical system by Shewanellawith micromolar concentrations of COE correlates well with the succinate produced viafumarate reduction as determined by HPLC analysis. Confocal microscopy confirms incorporation of the COE into the microbes on the electrode surface. This work presents a unique strategy to induce favorable bioelectronic interactions for the production of reduced microbial metabolites.