MALDI-MS analysis and imaging of small molecule metabolites with 1,5-diaminonaphthalene (DAN)

MALDI-MS analysis and imaging of small molecule metabolites with 1,5-diaminonaphthalene (DAN)

1,5‐diaminonaphthalene (DAN) has previously been reported as an effective matrix for matrix‐assisted laser desorption ionization‐mass spectrometry of phospholipids. In the current work, we investigate the use of DAN as a matrix for small metabolite analysis in negative ion mode. DAN was found to pro...

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Veröffentlicht in:Journal of mass spectrometry. 2014-08, Vol.49 (8), p.737-741
Hauptverfasser: Korte, Andrew R., Lee, Young Jin
Format: Artikel
Sprache:eng
Schlagworte:
1,5-diaminonaphthalene
5-diaminonaphthalene
Corn
Desorption
Diphosphates
Governments
Imaging
Ions
Lasers
MALDI
Mass spectrometry
mass spectrometry imaging
MATERIALS SCIENCE
matrix
Metabolites
Phospholipids
small molecules
Spectrometry
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Zusammenfassung:1,5‐diaminonaphthalene (DAN) has previously been reported as an effective matrix for matrix‐assisted laser desorption ionization‐mass spectrometry of phospholipids. In the current work, we investigate the use of DAN as a matrix for small metabolite analysis in negative ion mode. DAN was found to provide superior ionization to the compared matrices for MW 
ISSN:1076-5174
1096-9888
DOI:10.1002/jms.3400