Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tu...

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Veröffentlicht in:Applied radiation and isotopes 2014-06, Vol.88, p.64-68
Hauptverfasser: Garabalino, Marcela A., Heber, Elisa M., Monti Hughes, Andrea, Pozzi, Emiliano C.C., Molinari, Ana J., Nigg, David W., Bauer, William, Trivillin, Verónica A., Schwint, Amanda E.
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Sprache:eng
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Zusammenfassung:Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70–85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy. •We study the biodistribution of BPA+BSH for BNCT in experimental oral cancer.•The 3 BPA+BSH protocols assayed are potentially therapeutic.•Different proportions of B compounds with different CBE factors will affect response.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2013.11.118