Beyond small-angle x-ray scattering: Exploiting angular correlations

We propose a method for determining the projected electron density of an individual molecule from diffraction patterns of many such simultaneously illuminated molecules, randomly oriented about an axis parallel to an incident x-ray beam. We illustrate the idea with a simulation of a structure determ...

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Veröffentlicht in:	Physical review. B, Condensed matter and materials physics Condensed matter and materials physics, 2010-05, Vol.81 (17), Article 174105
Hauptverfasser:	Saldin, D. K., Poon, H. C., Shneerson, V. L., Howells, M., Chapman, H. N., Kirian, R. A., Schmidt, K. E., Spence, J. C. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES X-Ray Scattering Randomly Oriented Molecules
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Beschreibung
Zusammenfassung:	We propose a method for determining the projected electron density of an individual molecule from diffraction patterns of many such simultaneously illuminated molecules, randomly oriented about an axis parallel to an incident x-ray beam. We illustrate the idea with a simulation of a structure determination of a K-channel membrane protein in situ.
ISSN:	1098-0121 1550-235X
DOI:	10.1103/PhysRevB.81.174105