"Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model
Boron Neutron Capture Therapy (BNCT) is a binary treatment modality that involves the selective accumulation of 10B carriers in tumors followed by irradiation with a thermal or epithermal neutron beam. The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to...
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| Veröffentlicht in: | Radiation research 2011-04, Vol.175 (4) |
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| container_title | Radiation research |
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| creator | Ana J. Molinari Andrea Monti Hughes Elisa M. Heber Marcela A. Garabalino Veronica A. Trivillin Amanda E. Schwint Emiliano C. C. Pozzi Maria E. Itoiz Silvia I. Thorp Romina F. Aromando David W. Nigg Jorge Quintana Gustavo A. Santa Cruz |
| description | Boron Neutron Capture Therapy (BNCT) is a binary treatment modality that involves the selective accumulation of 10B carriers in tumors followed by irradiation with a thermal or epithermal neutron beam. The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to produce high linear energy transfer (LET) a-particles and 7Li ions. These disintegration products are known to have a high relative biological effectiveness (RBE). Their short range ( |
| doi_str_mv | 10.1667/RR2148.1 |
| format | Article |
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Molinari ; Andrea Monti Hughes ; Elisa M. Heber ; Marcela A. Garabalino ; Veronica A. Trivillin ; Amanda E. Schwint ; Emiliano C. C. Pozzi ; Maria E. Itoiz ; Silvia I. Thorp ; Romina F. Aromando ; David W. Nigg ; Jorge Quintana ; Gustavo A. Santa Cruz</creator><creatorcontrib>Ana J. Molinari ; Andrea Monti Hughes ; Elisa M. Heber ; Marcela A. Garabalino ; Veronica A. Trivillin ; Amanda E. Schwint ; Emiliano C. C. Pozzi ; Maria E. Itoiz ; Silvia I. Thorp ; Romina F. Aromando ; David W. Nigg ; Jorge Quintana ; Gustavo A. Santa Cruz ; Idaho National Laboratory (INL)</creatorcontrib><description>Boron Neutron Capture Therapy (BNCT) is a binary treatment modality that involves the selective accumulation of 10B carriers in tumors followed by irradiation with a thermal or epithermal neutron beam. The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to produce high linear energy transfer (LET) a-particles and 7Li ions. These disintegration products are known to have a high relative biological effectiveness (RBE). Their short range (<10 {micro}m) would limit the damage to cells containing 10B (1,2). Thus, BNCT would target tumor tissue selectively, sparing normal tissue. Clinical trials of BNCT for the treatment of glioblastoma multiforme and/or melanoma and, more recently, head and neck tumors and liver metastases, using boronophenylalanine (BPA) or sodium mercaptoundecahydrododecaborane (BSH) as the 10B carriers, have been performed or are underway in Argentina, Japan, the US and Europe (e.g. 3-8). To date, the clinical results have shown a potential, albeit inconclusive, therapeutic advantage for this technique. 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Santa Cruz</creatorcontrib><creatorcontrib>Idaho National Laboratory (INL)</creatorcontrib><title>"Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model</title><title>Radiation research</title><description>Boron Neutron Capture Therapy (BNCT) is a binary treatment modality that involves the selective accumulation of 10B carriers in tumors followed by irradiation with a thermal or epithermal neutron beam. The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to produce high linear energy transfer (LET) a-particles and 7Li ions. These disintegration products are known to have a high relative biological effectiveness (RBE). Their short range (<10 {micro}m) would limit the damage to cells containing 10B (1,2). Thus, BNCT would target tumor tissue selectively, sparing normal tissue. Clinical trials of BNCT for the treatment of glioblastoma multiforme and/or melanoma and, more recently, head and neck tumors and liver metastases, using boronophenylalanine (BPA) or sodium mercaptoundecahydrododecaborane (BSH) as the 10B carriers, have been performed or are underway in Argentina, Japan, the US and Europe (e.g. 3-8). To date, the clinical results have shown a potential, albeit inconclusive, therapeutic advantage for this technique. Contributory translational studies have been carried out employing a variety of experimental models based on the implantation of tumor cells in normal tissue (e.g. 5).</description><subject>ABUNDANCE</subject><subject>BORON</subject><subject>Boron Neutron Capture Therapy (BNCT)</subject><subject>CLINICAL TRIALS</subject><subject>EPITHERMAL NEUTRONS</subject><subject>GLIOMAS</subject><subject>HAMSTERS</subject><subject>IRRADIATION</subject><subject>LET</subject><subject>LIVER</subject><subject>MELANOMAS</subject><subject>METASTASES</subject><subject>NEOPLASMS</subject><subject>NEUTRON CAPTURE THERAPY</subject><subject>NEUTRONS</subject><subject>oral cancer</subject><subject>PHYSICS OF ELEMENTARY PARTICLES AND FIELDS</subject><subject>RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RBE</subject><subject>SODIUM</subject><subject>STABLE ISOTOPES</subject><subject>TARGETS</subject><subject>TUMOR CELLS</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqNjE1OwzAUhC0EEuFH4ghPXcEixU7SJGXXRqBuCKhkX1nmRQm4fsF2kNj1BpyAy3ESXMQBWH0azczH2IXgU5HnxfV6nYisnIoDFol5WsazjGeHLOI8TeNiVhbH7MS5Fx6yyOcR-5w84duIxvdSf---YEmWDNQ4-j0rOfjRIjQdWjl8wOWyrpqrG1hATe-oYTEMlqTqwBPsK2jJgu_CwaL026AFauHBSh1URqGF3vz2K7l1PsSqQ3yFRxqD456eUZ-xo1Zqh-d_PGWTu9umWsXkfL9xqveoOkXGoPIbwdM8yZP0X6MfoPNYeA</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Ana J. 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The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to produce high linear energy transfer (LET) a-particles and 7Li ions. These disintegration products are known to have a high relative biological effectiveness (RBE). Their short range (<10 {micro}m) would limit the damage to cells containing 10B (1,2). Thus, BNCT would target tumor tissue selectively, sparing normal tissue. Clinical trials of BNCT for the treatment of glioblastoma multiforme and/or melanoma and, more recently, head and neck tumors and liver metastases, using boronophenylalanine (BPA) or sodium mercaptoundecahydrododecaborane (BSH) as the 10B carriers, have been performed or are underway in Argentina, Japan, the US and Europe (e.g. 3-8). To date, the clinical results have shown a potential, albeit inconclusive, therapeutic advantage for this technique. 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| source | Jstor Complete Legacy; BioOne Complete |
| subjects | ABUNDANCE BORON Boron Neutron Capture Therapy (BNCT) CLINICAL TRIALS EPITHERMAL NEUTRONS GLIOMAS HAMSTERS IRRADIATION LET LIVER MELANOMAS METASTASES NEOPLASMS NEUTRON CAPTURE THERAPY NEUTRONS oral cancer PHYSICS OF ELEMENTARY PARTICLES AND FIELDS RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY RADIOLOGY AND NUCLEAR MEDICINE RBE SODIUM STABLE ISOTOPES TARGETS TUMOR CELLS |
| title | "Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model |
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