"Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model

Boron Neutron Capture Therapy (BNCT) is a binary treatment modality that involves the selective accumulation of 10B carriers in tumors followed by irradiation with a thermal or epithermal neutron beam. The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to...

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Veröffentlicht in:	Radiation research 2011-04, Vol.175 (4)
Hauptverfasser:	Ana J. Molinari, Andrea Monti Hughes, Elisa M. Heber, Marcela A. Garabalino, Veronica A. Trivillin, Amanda E. Schwint, Emiliano C. C. Pozzi, Maria E. Itoiz, Silvia I. Thorp, Romina F. Aromando, David W. Nigg, Jorge Quintana, Gustavo A. Santa Cruz
Format:	Artikel
Sprache:	eng
Schlagworte:	ABUNDANCE BORON Boron Neutron Capture Therapy (BNCT) CLINICAL TRIALS EPITHERMAL NEUTRONS GLIOMAS HAMSTERS IRRADIATION LET LIVER MELANOMAS METASTASES NEOPLASMS NEUTRON CAPTURE THERAPY NEUTRONS oral cancer PHYSICS OF ELEMENTARY PARTICLES AND FIELDS RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY RADIOLOGY AND NUCLEAR MEDICINE RBE SODIUM STABLE ISOTOPES TARGETS TUMOR CELLS
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Zusammenfassung:	Boron Neutron Capture Therapy (BNCT) is a binary treatment modality that involves the selective accumulation of 10B carriers in tumors followed by irradiation with a thermal or epithermal neutron beam. The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to produce high linear energy transfer (LET) a-particles and 7Li ions. These disintegration products are known to have a high relative biological effectiveness (RBE). Their short range (
ISSN:	0033-7587 1938-5404
DOI:	10.1667/RR2148.1