Regulatory Effect of Scutellariae Radix on the Proinflammatory Cytokine Production and Abnormal T-Cell Activation in Vitro in Pristane-Induced Lupus Mice

Scutellaria baicalensis is known as a herbal medicine with anti-inflammatory and anti-oxidative activities. However, effect of Scutellaria baicalensis on lupus pathogenesis that is characterized by overproduction of proinflammatory cytokines and abnormalities in regulation, function, and interaction...

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Veröffentlicht in:	Natural product sciences 2007-09, Vol.13 (3), p.207-213
Hauptverfasser:	Chae, B.S. (Woosuk University, Wanju, Republic of Korea), E-mail: cbse@woosuk.ac.kr, Shin, T.Y. (Woosuk University, Wanju, Republic of Korea), Oh, C.H. (Woosuk University, Wanju, Republic of Korea), Kim, D.K. (Woosuk University, Wanju, Republic of Korea), Eun, J.S. (Woosuk University, Wanju, Republic of Korea), Jeon, H. (Woosuk University, Wanju, Republic of Korea), Park, J.S. (Nambu University, Gwangju, Republic of Korea), Kim, M.S. (Woosuk University, Wanju, Republic of Korea), Yang, J.H. (Woosuk University, Wanju, Republic of Korea)
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4 CD69 CD8 DRUG PLANTS IL-10 IL-6 lupus PLANTAS MEDICINALES PLANTE MEDICINALE pristane Scutellariae radix
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Beschreibung
Zusammenfassung:	Scutellaria baicalensis is known as a herbal medicine with anti-inflammatory and anti-oxidative activities. However, effect of Scutellaria baicalensis on lupus pathogenesis that is characterized by overproduction of proinflammatory cytokines and abnormalities in regulation, function, and interaction of immune cells remains unclear. We investigated effects of Scutellariae radix methanol extract (SBMeOH) on the production of proinflammatory cytokines and abnormal activation of T cells in vitro in pristane-induced lupus BALB/c mice.
ISSN:	1226-3907 2288-9027