Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells
Dietary flavonoids have antioxidant and antitumor promoting effects. Rhus verniciflua Stokes (RVS) is a flavonoid-rich herbal medicine and has long been used as a food additive and an antitumor agent in Korea. Previous study demonstrated that a purified flavonoid fraction prepared from RVS, herein n...
Gespeichert in:
| Veröffentlicht in: | Natural product sciences 2007-03, Vol.13 (1), p.1-5 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Natural product sciences |
| container_volume | 13 |
| creator | Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea) Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea) Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea) Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea) Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea) Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea) Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea) Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea) Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea) Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr |
| description | Dietary flavonoids have antioxidant and antitumor promoting effects. Rhus verniciflua Stokes (RVS) is a flavonoid-rich herbal medicine and has long been used as a food additive and an antitumor agent in Korea. Previous study demonstrated that a purified flavonoid fraction prepared from RVS, herein named RCMF (the RVS chloroform-methanol fraction), exhibited growth inhibition and induced apoptosis in human osteosarcoma (HOS) cells. This study evaluated if p53-mediated pathway is associated with the RCMF-induced apoptosis in HOS cells. |
| format | Article |
| fullrecord | <record><control><sourceid>nurimedia_fao_a</sourceid><recordid>TN_cdi_nurimedia_primary_NODE11129368</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><nurid>NODE11129368</nurid><sourcerecordid>NODE11129368</sourcerecordid><originalsourceid>FETCH-LOGICAL-f122t-661763cbbe15cd6d777354dc0d08a5d421757d12cc292daebb9bbd3278c72db43</originalsourceid><addsrcrecordid>eNotkF1LwzAUhosoOKc_QciNl4V8tE17OebmhpuTqdclX3XRNilJWthP8d8uOq_O4fDwcN73IplgXJZpBTG9TCYI4yIlFaTXyY33XxAWiKBskvyszWjbUXXKBGAb0Ock3SqpWVASbHWw4mCNdJq14C045T3QBoSDArPe9sF67cHayEFEmh_BsmWjNVZLD14Hpxsdz42zHdgfBg9G5YwWumkHFmX2W_3JVkPHDNj5oKxnTtiOgblqW3-bXDWs9eruf06Tj-Xifb5KN7un9Xy2SZuYKaRFgWhBBOcK5UIWklJK8kwKKGHJcplhRHMqERYCV1gyxXnFuSSYloJiyTMyTR7OXhM_7n6j131cmDvWL7vHBUIIV6QoI3d_5hpma_bptK-f9xhCCmFsEpITBL1wfA</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea) ; Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea) ; Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea) ; Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea) ; Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea) ; Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea) ; Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr</creator><creatorcontrib>Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea) ; Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea) ; Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea) ; Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea) ; Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea) ; Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea) ; Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr</creatorcontrib><description>Dietary flavonoids have antioxidant and antitumor promoting effects. Rhus verniciflua Stokes (RVS) is a flavonoid-rich herbal medicine and has long been used as a food additive and an antitumor agent in Korea. Previous study demonstrated that a purified flavonoid fraction prepared from RVS, herein named RCMF (the RVS chloroform-methanol fraction), exhibited growth inhibition and induced apoptosis in human osteosarcoma (HOS) cells. This study evaluated if p53-mediated pathway is associated with the RCMF-induced apoptosis in HOS cells.</description><identifier>ISSN: 1226-3907</identifier><identifier>EISSN: 2288-9027</identifier><language>eng</language><publisher>한국생약학회</publisher><subject>APOPTOSE ; APOPTOSIS ; FLAVONOIDE ; FLAVONOIDES ; FLAVONOIDS ; human osteosarcoma cells ; mitochondrial stress ; p53</subject><ispartof>Natural product sciences, 2007-03, Vol.13 (1), p.1-5</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea)</creatorcontrib><creatorcontrib>Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr</creatorcontrib><title>Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells</title><title>Natural product sciences</title><description>Dietary flavonoids have antioxidant and antitumor promoting effects. Rhus verniciflua Stokes (RVS) is a flavonoid-rich herbal medicine and has long been used as a food additive and an antitumor agent in Korea. Previous study demonstrated that a purified flavonoid fraction prepared from RVS, herein named RCMF (the RVS chloroform-methanol fraction), exhibited growth inhibition and induced apoptosis in human osteosarcoma (HOS) cells. This study evaluated if p53-mediated pathway is associated with the RCMF-induced apoptosis in HOS cells.</description><subject>APOPTOSE</subject><subject>APOPTOSIS</subject><subject>FLAVONOIDE</subject><subject>FLAVONOIDES</subject><subject>FLAVONOIDS</subject><subject>human osteosarcoma cells</subject><subject>mitochondrial stress</subject><subject>p53</subject><issn>1226-3907</issn><issn>2288-9027</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNotkF1LwzAUhosoOKc_QciNl4V8tE17OebmhpuTqdclX3XRNilJWthP8d8uOq_O4fDwcN73IplgXJZpBTG9TCYI4yIlFaTXyY33XxAWiKBskvyszWjbUXXKBGAb0Ock3SqpWVASbHWw4mCNdJq14C045T3QBoSDArPe9sF67cHayEFEmh_BsmWjNVZLD14Hpxsdz42zHdgfBg9G5YwWumkHFmX2W_3JVkPHDNj5oKxnTtiOgblqW3-bXDWs9eruf06Tj-Xifb5KN7un9Xy2SZuYKaRFgWhBBOcK5UIWklJK8kwKKGHJcplhRHMqERYCV1gyxXnFuSSYloJiyTMyTR7OXhM_7n6j131cmDvWL7vHBUIIV6QoI3d_5hpma_bptK-f9xhCCmFsEpITBL1wfA</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea)</creator><creator>Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea)</creator><creator>Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea)</creator><creator>Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea)</creator><creator>Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea)</creator><creator>Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea)</creator><creator>Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea)</creator><creator>Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea)</creator><creator>Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea)</creator><creator>Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr</creator><general>한국생약학회</general><scope>FBQ</scope><scope>DBRKI</scope><scope>TDB</scope></search><sort><creationdate>200703</creationdate><title>Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells</title><author>Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea) ; Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea) ; Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea) ; Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea) ; Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea) ; Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea) ; Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea) ; Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f122t-661763cbbe15cd6d777354dc0d08a5d421757d12cc292daebb9bbd3278c72db43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>APOPTOSE</topic><topic>APOPTOSIS</topic><topic>FLAVONOIDE</topic><topic>FLAVONOIDES</topic><topic>FLAVONOIDS</topic><topic>human osteosarcoma cells</topic><topic>mitochondrial stress</topic><topic>p53</topic><toplevel>online_resources</toplevel><creatorcontrib>Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea)</creatorcontrib><creatorcontrib>Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea)</creatorcontrib><creatorcontrib>Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr</creatorcontrib><collection>AGRIS</collection><collection>DBPIA - 디비피아</collection><collection>DBPIA</collection><jtitle>Natural product sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea)</au><au>Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea)</au><au>Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea)</au><au>Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea)</au><au>Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea)</au><au>Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea)</au><au>Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea)</au><au>Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea)</au><au>Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea)</au><au>Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells</atitle><jtitle>Natural product sciences</jtitle><date>2007-03</date><risdate>2007</risdate><volume>13</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>1226-3907</issn><eissn>2288-9027</eissn><abstract>Dietary flavonoids have antioxidant and antitumor promoting effects. Rhus verniciflua Stokes (RVS) is a flavonoid-rich herbal medicine and has long been used as a food additive and an antitumor agent in Korea. Previous study demonstrated that a purified flavonoid fraction prepared from RVS, herein named RCMF (the RVS chloroform-methanol fraction), exhibited growth inhibition and induced apoptosis in human osteosarcoma (HOS) cells. This study evaluated if p53-mediated pathway is associated with the RCMF-induced apoptosis in HOS cells.</abstract><pub>한국생약학회</pub><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1226-3907 |
| ispartof | Natural product sciences, 2007-03, Vol.13 (1), p.1-5 |
| issn | 1226-3907 2288-9027 |
| language | eng |
| recordid | cdi_nurimedia_primary_NODE11129368 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | APOPTOSE APOPTOSIS FLAVONOIDE FLAVONOIDES FLAVONOIDS human osteosarcoma cells mitochondrial stress p53 |
| title | Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T00%3A31%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-nurimedia_fao_a&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Involvement%20of%20p53-Mediated%20Mitochondrial%20Stress%20in%20the%20Apoptosis%20Induced%20by%20Flavonoids%20Purified%20from%20Rhus%20verniciflua%20Stokes%20in%20Human%20Osteosarcoma%20Cells&rft.jtitle=Natural%20product%20sciences&rft.au=Chung,%20S.W.%20(Chonbuk%20National%20University,%20Jeonju,%20Republic%20of%20Korea)&rft.date=2007-03&rft.volume=13&rft.issue=1&rft.spage=1&rft.epage=5&rft.pages=1-5&rft.issn=1226-3907&rft.eissn=2288-9027&rft_id=info:doi/&rft_dat=%3Cnurimedia_fao_a%3ENODE11129368%3C/nurimedia_fao_a%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_nurid=NODE11129368&rfr_iscdi=true |