Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells

Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells

Dietary flavonoids have antioxidant and antitumor promoting effects. Rhus verniciflua Stokes (RVS) is a flavonoid-rich herbal medicine and has long been used as a food additive and an antitumor agent in Korea. Previous study demonstrated that a purified flavonoid fraction prepared from RVS, herein n...

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Veröffentlicht in:Natural product sciences 2007-03, Vol.13 (1), p.1-5
Hauptverfasser: Chung, S.W. (Chonbuk National University, Jeonju, Republic of Korea), Lee, S.A. (Chonnam Techno College, Gokseong, Republic of Korea), Park, J.S. (Chonbuk National University, Jeonju, Republic of Korea), Ryu, K.W. (Chonbuk National University, Jeonju, Republic of Korea), Jang, M.J. (Chonbuk National University, Jeonju, Republic of Korea), Park, S.S. (Chonbuk National University, Jeonju, Republic of Korea), Lee, C.B. (Chonbuk National University, Jeonju, Republic of Korea), Kim, J.G. (Chonbuk National University, Jeonju, Republic of Korea), Jeon, Y.M. (Chonbuk National University, Jeonju, Republic of Korea), Lee, J.C. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: leejc88@chonbuk.ac.kr
Format: Artikel
Sprache:eng
Schlagworte:
APOPTOSE
APOPTOSIS
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
human osteosarcoma cells
mitochondrial stress
p53
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Zusammenfassung:Dietary flavonoids have antioxidant and antitumor promoting effects. Rhus verniciflua Stokes (RVS) is a flavonoid-rich herbal medicine and has long been used as a food additive and an antitumor agent in Korea. Previous study demonstrated that a purified flavonoid fraction prepared from RVS, herein named RCMF (the RVS chloroform-methanol fraction), exhibited growth inhibition and induced apoptosis in human osteosarcoma (HOS) cells. This study evaluated if p53-mediated pathway is associated with the RCMF-induced apoptosis in HOS cells.
ISSN:1226-3907
2288-9027