Studies on the Anti-Inflammatory and Analgesic Effects of Extracts from Marine Sponges

Studies on the Anti-Inflammatory and Analgesic Effects of Extracts from Marine Sponges

Two specimens of sponges collected from Red Sea, Egypt, were investigated for their contents of secondary metabolites. The crude extracts of the sponges were tested for their anti-inflammatory and analgesic effects. The toxic effects of the extracts of the two marine sponges were studied. LD∧50 dete...

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Veröffentlicht in:Natural product sciences 2006-06, Vol.12 (2), p.74-78
Hauptverfasser: Fakhr, Issa M.I. (Dept. of Applied Org. Chem.), Hamdy, Nehal A. (Dept. of Applied Org. Chem.), Radwan, Mohamed A.A. (Dept. of Applied Org. Chem.), El-Batran, Seham a. (National Research Center, Dokki, Giza(Egypt)), E-mail: sehamelbatran@yahoo.com, Shabrawy, Osama A. (National Research Center, Dokki, Giza(Egypt))
Format: Artikel
Sprache:eng
Schlagworte:
ANALGESICOS
ANALGESICS
ANALGESIQUE
anti-inflammatory
EPONGE
ESPONJAS
Igernella
Ircinia
SPONGES
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Zusammenfassung:Two specimens of sponges collected from Red Sea, Egypt, were investigated for their contents of secondary metabolites. The crude extracts of the sponges were tested for their anti-inflammatory and analgesic effects. The toxic effects of the extracts of the two marine sponges were studied. LD∧50 determination revealed that the investigated extracts of 'Igernella and Ircinia spp' were 4.69 and 134.7 mg/100 g b.wt., respectively, when injected intraperitoneally in mice. The toxic signs were recorded within the first 24 hrs after injection. Also the two marine sponges extracts showed significant anti-inflammatory and analgesic effects.
ISSN:1226-3907
2288-9027