Honokiol : A Noncompetitive Tyrosinase Inhibitor from Magnoliae Cortex

Honokiol : A Noncompetitive Tyrosinase Inhibitor from Magnoliae Cortex

Effect of the neolignans, honokiol (1) and magnolol (2), isolated from Magnoliae Cortex on mushroom tyrosinase activity was investigated in vitro using L-tyrosine as a substrate. Honokiol (1) inhibited tyrosinase activity significantly in a concentration-dependent manner, on the other hand, magnolol...

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Veröffentlicht in:Natural product sciences 2005-06, Vol.11 (2), p.89-91
Hauptverfasser: Tian, Yu-Hua (Wonkwang University, Iksan, Republic of Korea), Kang, T.H. (Wonkwang University, Iksan, Republic of Korea), Kim, H.C. (Wonkwang University, Iksan, Republic of Korea), Kim, Y.C. (Wonkwang University, Iksan, Republic of Korea), E-mail: yckim@wonkwang.ac.kr
Format: Artikel
Sprache:eng
Schlagworte:
DRUG PLANTS
Honokiol
Magnoliae Cortex
PLANTAS MEDICINALES
PLANTE MEDICINALE
Tyrosinase inhibitor
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Zusammenfassung:Effect of the neolignans, honokiol (1) and magnolol (2), isolated from Magnoliae Cortex on mushroom tyrosinase activity was investigated in vitro using L-tyrosine as a substrate. Honokiol (1) inhibited tyrosinase activity significantly in a concentration-dependent manner, on the other hand, magnolol (2) did not show tyrosinase inhibitory effect. Honokiol exhibited tyrosinase inhibitory effect with IC∧50 value of 67.9 μM, and proved to act as a non-competitive inhibitor by the analysis of Lineweaver-Burk plot.
ISSN:1226-3907
2288-9027