Influence of β-Eudesmol on Blood Pressure

The present study was undertaken to investigate the effects of β-eudesmol, one of various ingredients isolated and identified from the bark of Magnolia obovata Thunberg, on arterial blood pressure and vascular contractile responses in the normotensve rats and to establish its mechanism of action. β-Eudesmol (30~300 ㎍/kg) given into a femoral vein of the normotensive rat produced a dose-dependent depressor response. These β-eudesmol-induced hypotensive responses were markedly inhibited in the presence of chlorisondamine (1.0 mg/kg, i.v.) or phentolamine (2.0 mg/kg, i.v.).