Anticancer Potency of Terminalia arjuna Bark on N-nitrosodiethylamine-Induced Hepatocellular Carcinoma in Rats

Anticancer Potency of Terminalia arjuna Bark on N-nitrosodiethylamine-Induced Hepatocellular Carcinoma in Rats

The anticancer potency of the ethanolic extract of Terminalia arjuna on N-nitrosodiethylamine (DEN) induced hepatocellular carcinoma in Wistar albino rats was studied. Single intraperitoneal injection of DEN was administrated to induce liver cancer. After two weeks, phenobarbital (PB) was given oral...

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Veröffentlicht in:Natural product sciences 2004-08, Vol.10 (4), p.190-195
Hauptverfasser: Sivalokanathan, Sarveswaran (University of Madras, Chennai, Tamil Nadu, India), Ilayaraja, Muthaiyan (University of Madras, Chennai, Tamil Nadu, India), Balasubramanian, Maruthaiveeran Periyasamy (University of Madras, Chennai, Tamil Nadu, India), E-mail: mpbpet@rediffmail.com
Format: Artikel
Sprache:eng
Schlagworte:
Aminotransaminases
Hepatocellular carcinoma
LACTATE DEHYDROGENASE
LACTATE DESHYDROGENASE
LACTATO DESHIDROGENASA
N-nitrosodiethylamine
Phosphatases
Terminalia arjuna
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Zusammenfassung:The anticancer potency of the ethanolic extract of Terminalia arjuna on N-nitrosodiethylamine (DEN) induced hepatocellular carcinoma in Wistar albino rats was studied. Single intraperitoneal injection of DEN was administrated to induce liver cancer. After two weeks, phenobarbital (PB) was given orally for fourteen weeks to promote the cancer. The cancer bearing animals treated with ethanolic extract of T.arjuna (400 mg/kg body weight) for 28days. Nucleic such as deoxyribonucleic acid (DNA) and ribonucleic (RNA) were estimated in liver and kidney of control and experimental animals.
ISSN:1226-3907
2288-9027