Latilactobacillus curvatus BYB3 Isolated from Kimchi Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice by Inhibiting IL-6 and TNF-R1 Production
Recent studies have shown that probiotics have health-promoting effects, particularly intestinal immune modulation. In this study, we focused on the immunomodulatory properties of BYB3, formerly called , isolated from kimchi. In a mouse model of 14-day dextran sulfate sodium (DSS)-induced colitis, t...
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Veröffentlicht in: | Journal of microbiology and biotechnology 2022, 32(3), , pp.348-354 |
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Sprache: | eng |
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Zusammenfassung: | Recent studies have shown that probiotics have health-promoting effects, particularly intestinal immune modulation. In this study, we focused on the immunomodulatory properties of
BYB3, formerly called
, isolated from kimchi. In a mouse model of 14-day dextran sulfate sodium (DSS)-induced colitis, treatment with
BYB3 significantly decreased the disease activity index, colon length, and weight loss. Moreover, histological analyses showed that
BYB3 protected the structural integrity of the intestinal epithelial layer and mucin-secreting goblet cells from DSS-induced damage, with only slight infiltration by immune cells. To evaluate the molecular mechanisms underlying
BYB3-driven inhibition of interleukin 6 production, possible in vivo anti-inflammatory effects of
BYB3 were examined in the same mouse model. In addition, significantly lower levels of IL-6 and tumor necrosis factor receptor 1 upregulation were seen in the DSS+BYB3 group (compared to that in the DSS group). These results indicate that
BYB3 exhibits health-promoting effects via immune modulation; and therefore, it can be used to treat various inflammatory diseases. |
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ISSN: | 1017-7825 1738-8872 |
DOI: | 10.4014/jmb.2109.09054 |