Improving pharmacologically relevant properties of sulfasalazine loaded in r-cyclodextrin-based metal organic framework

The aim of this work was to improve the dissolution properties of poorly soluble drug sulfasalazine (SSZ)by encapsulation in the metal organic framework based on c-cyclodextrin (cCD-MOF). Loading of SSZ inthe framework was successfully performed by impregnation and co-crystallization methods. Theobt...

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Veröffentlicht in:Journal of industrial and engineering chemistry (Seoul, Korea) 2022, 106(0), , pp.189-197
Hauptverfasser: Mikhail Agafonov, Anna Garibyan, Irina Terekhova
Format: Artikel
Sprache:eng
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Zusammenfassung:The aim of this work was to improve the dissolution properties of poorly soluble drug sulfasalazine (SSZ)by encapsulation in the metal organic framework based on c-cyclodextrin (cCD-MOF). Loading of SSZ inthe framework was successfully performed by impregnation and co-crystallization methods. Theobtained composites cCD-MOF/SSZ were investigated by several methods, including PXRD, N2 physisorption,FTIR, solid 13C NMR, SEM, and DLS. The SSZ release from cCD-MOF was examined with in vitro dissolutionstudies using simulated gastric and intestinal fluids. Sulfasalazine loaded in cCD-MOF exhibitedthe improved release. Release profiles of SSZ were compared and analyzed using different kinetic models. Some efforts were made to reduce the burst release of SSZ from cCD-MOF in the phosphate buffer (pH6.8). Influence of c-cyclodextrin on the membrane permeability of SSZ was examined. KCI Citation Count: 1
ISSN:1226-086X
1876-794X