갯벌 방선균 유래 Boholamide A의 구조 및 생리활성에 대한 연구

갯벌 방선균 유래 Boholamide A의 구조 및 생리활성에 대한 연구

LC/MS approach targeting secondary metabolites of bacterial strain resulted in the discovery of boholamide A (1), from the culture of marine actinomycete strain which was isolated from a tidal mudflat in Muan, Republic of Korea. Boholamide A (1), a cyclodepsipeptide with HDMN, APD, glycine, and vali...

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Veröffentlicht in:생약학회지 2021, 52(4), 207, pp.203-207
Hauptverfasser: 서정원(Jeongwon Seo), 문규호(Kyuho Moon)
Format: Artikel
Sprache:kor
Schlagworte:
약학
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Zusammenfassung:LC/MS approach targeting secondary metabolites of bacterial strain resulted in the discovery of boholamide A (1), from the culture of marine actinomycete strain which was isolated from a tidal mudflat in Muan, Republic of Korea. Boholamide A (1), a cyclodepsipeptide with HDMN, APD, glycine, and valine was structurally determined by using 1D/2D NMR spectroscopy, mass spectrometry and UV spectroscopy. Boholamide A (1) showed the inhibitory activity against Bacillus subtilis, with IC50 value of 0.08 mM.
ISSN:0253-3073
2288-9299
DOI:10.22889/KJP.2021.52.4.203